Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production
Viktoriya Zhuravleva, João Vaz‐Silva, Mei J. Zhu, Patrícia Gomes, Joana Margarida Silva, Nuno Sousa, Ioannis Sotiropoulos, Clarissa L. Waites
This study shows Rab35 regulates APP and BACE1 trafficking to reduce Aβ production, and its downregulation by stress and aging contributes to amyloidogenesis.
Cell Death and Disease · Dec 7, 2021Peer-reviewedNeuroscience