Nuno Sousa

This paper introduces a Hodge-Laplacian framework to analyze higher-order topology in OCD brain networks, identifying loop-level abnormalities not detectable by conventional functional connectivity analysis.

This study shows that loss of normal Tau function in the adult brain causes neuronal atrophy, epigenetic changes, and cognitive/mood deficits, which can be reversed by Tau re-expression or epigenetic correction.

The paper identifies miR-122-5p and miR-1247 as regulators of Th17 and Th1 cell functions in autoimmune inflammation, affecting EAE severity.

The paper shows that D1- and D2-MSNs in the NAc shell encode appetitive and aversive stimuli and their extinction, with D2-MSNs playing a key role in aversive association extinction.

The paper examines how maternal depressive symptoms and hair cortisol concentration during pregnancy predict neonatal corpus callosum integrity using MRI and DTI data.

This study identifies Foxo1 as a key regulator of astrocytic calcium signaling in the hippocampus, influencing spinogenesis, synaptic plasticity, and fear memory.

This study examines how D1- and D2-neurons in the nucleus accumbens encode positive and aversive associations during Pavlovian conditioning, showing dynamic changes in their activity.

This study examines the long-term effects of prenatal synthetic glucocorticoid exposure on adolescent brain structure and function using MRI, finding no structural differences but altered functional connectivity.

This study shows that activating D2-MSN projections to the ventral pallidum increases anxious-like behavior in mice, linked to reduced GABAergic activity in the VP.

This study shows that D2-MSN projections to the ventral pallidum have opposing effects on motivation depending on the phase of motivated behavior.

This study shows Rab35 regulates APP and BACE1 trafficking to reduce Aβ production, and its downregulation by stress and aging contributes to amyloidogenesis.

This study shows that AP2gamma deficiency in mice reduces hippocampal neurogenesis and causes lasting behavioral deficits from juvenile to adult stages.

This study shows that Meth exposure causes microglia reactivity through astrocyte-derived TNF and glutamate, affecting behavior in adult mice.

The paper integrates differential gene expression with WGCNA to identify aging-related expression signatures in mouse tissues, revealing common proteostasis pathways across multiple organs.

The paper develops a versatile and modular tetrode-based device for interchangeable extracellular recordings in both in vivo and ex vivo rodent brain preparations.

This study uses fMRI to examine neural dynamics during jazz improvisation, finding distinct brain network patterns for different improvisation modes and their cognitive mechanisms.

The paper develops and validates a behavioral and EEG-based anesthesia scale for rodents, showing dose-dependent progression and reversal patterns.

The paper shows that the cerebral cortex operates near a critical phase transition in spiking variability, with critical exponents distinct from mean-field directed percolation.

This study shows that glucocorticoids impair Tau degradation via the Rab35/ESCRT pathway, leading to Tau accumulation and hippocampal dysfunction.

This study uses whole-brain computational modeling to analyze how deep brain stimulation affects brain dynamics in Parkinson’s disease patients, finding it shifts brain states closer to healthy dynamics.