Nikolaos P. Daskalakis

This study examines changes in anterior cingulate cortex connectivity in response to antidepressant treatment in MDD patients, finding distinct patterns associated with treatment response and remission.

This study fine-maps PTSD GWAS data with amygdala eQTLs and shows FOXP2 expression is linked to increased PTSD risk, with functional validation in mice and humans.

The paper creates a miRNA atlas of the human prefrontal cortex across aging, identifying age-related miRNA changes and highlighting miR-34a-5p as a key upregulated miRNA in older individuals.

The paper identifies disease-specific circular RNAs in schizophrenia and bipolar disorder, linking them to genetic risk, synaptic biology, and brain structure through transcriptomic and imaging analyses.

This study maps molecular and genetic signatures of schizophrenia in human prefrontal cortex across spatial scales, revealing altered BDNF-TrkB signaling and inhibitory circuit dysfunction.

The paper performs spatial transcriptomics on the human prefrontal cortex across the lifespan to identify aging-related changes in different cortical layers.

The paper identifies molecular and anatomical diversity in human cortical astrocytes and links adversity and glucocorticoid signalling to glutamate-related synaptic dysfunction in psychiatric disorders.

The paper identifies 46,802 enhancers and 164 psychiatric disorder variants with regulatory effects in the developing cortex and organoids using massively parallel reporter assays and deep learning.

The paper generates a molecular neuroanatomical map of the human prefrontal cortex using spatial transcriptomics and single nucleus RNA-sequencing, revealing novel spatial domains and cell-cell interactions linked to psychiatric disorders.

The paper constructs a cross-ancestry, cell-type-informed gene regulatory atlas of the developing human brain, identifying genetic regulation and linking it to neuropsychiatric disorders.

The paper examines genetic correlations between PTSD and alcohol-related phenotypes, finding distinct genetic factors for AUD versus alcohol consumption.

The paper introduces JEPEGMIX2-P, a TWAS pathway method that improves computational efficiency and performance for psychiatric disorder GWAS, showing increased power over existing methods like MAGMA.

This paper improves psychiatric GWAS by re-imputing summary statistics using a larger, more diverse reference panel, revealing new signals from rare variants.

The paper identifies SNRNP35 as a trauma type-specific PTSD gene through analysis of genetically regulated gene expression in PTSD cases and controls.

The PTSD Biomarker Database compiles over 900 PTSD biomarkers from 109 studies to enable exploration and comparison of biomarker findings through interactive visualizations.

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.

This study shows that glucocorticoids impair Tau degradation via the Rab35/ESCRT pathway, leading to Tau accumulation and hippocampal dysfunction.

The paper identifies Drd2-expressing neurons in the central amygdala as a novel fear-supporting population and validates pharmacological targets for fear extinction.