Mei J. Zhu

This study shows Rab35 regulates APP and BACE1 trafficking to reduce Aβ production, and its downregulation by stress and aging contributes to amyloidogenesis.

The paper identifies a novel activity-dependent mechanism involving Hrs and KIF13A for axonal transport of ESCRT machinery to facilitate synaptic vesicle protein degradation.

This study shows that glucocorticoids impair Tau degradation via the Rab35/ESCRT pathway, leading to Tau accumulation and hippocampal dysfunction.

This study shows that Parkinson's disease-linked Parkin mutations impair glutamatergic synaptic transmission and plasticity by disrupting NMDA and AMPA receptor trafficking.