Aaron T. Crain

Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation

The paper shows that Set8 and L(3)mbt affect gene expression in Drosophila independently of H4K20 methylation, as their mutants have distinct transcriptomes despite similar H4K20me1 reductions.

Redesigning the Drosophila histone gene cluster: An improved genetic platform for spatiotemporal manipulation of histone function

The paper develops a new genetic platform in Drosophila to improve spatiotemporal manipulation of histone function through CRISPR and synthetic gene arrays.

Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster

This study shows that Set8/KMT5A and H4K20me1 have distinct roles in Drosophila development, with non-catalytic functions of Set8 and H4K20me1 contributing to viability and phenotypic differences.