Robert J. Duronio

This study shows that Drosophila Mute represses histone mRNA outside S phase and differentially regulates histone gene expression during S phase, leading to developmental defects when disrupted.

This study shows that availability of histone H3 is more critical for development than the specific subtype (H3.2 vs H3.3) in Drosophila.

The paper investigates how cell cycle regulation controls transcriptional pausing of Drosophila replication-dependent histone genes, showing that Cyclin E/Cdk2 activation drives full-length transcript production during S phase.

The paper shows that H3.2K4 antagonizes Polycomb group activity and promotes target gene expression in vivo.

The paper shows that Set8 and L(3)mbt affect gene expression in Drosophila independently of H4K20 methylation, as their mutants have distinct transcriptomes despite similar H4K20me1 reductions.

The paper develops a new genetic platform in Drosophila to improve spatiotemporal manipulation of histone function through CRISPR and synthetic gene arrays.

The paper shows that reduced canonical histone gene copy number in Drosophila disrupts Polycomb function, leading to developmental defects and ectopic sex combs.

The paper shows that H3.2 and H3.3 K36 residues have distinct roles in maintaining Polycomb silencing of Hox genes through different mechanisms, enabling development.

This study shows that Set8/KMT5A and H4K20me1 have distinct roles in Drosophila development, with non-catalytic functions of Set8 and H4K20me1 contributing to viability and phenotypic differences.

This study shows that cell lineage primarily determines replication timing, while Rif1, through its PP1-binding motif, fine-tunes RT in a tissue-specific manner in Drosophila.

The paper uses high-depth TSS mapping in D. melanogaster to identify novel initiation events and characterize enhancer-associated RNAs (eRNAs) in a developmental context.

The paper investigates the functional roles of K9 modifications on variant and canonical histone H3 in Drosophila, showing overlapping but distinct contributions to chromatin structure and gene regulation.

This study replaces H3K36 with arginine in Drosophila to show H3K36 methylation maintains transcriptome fidelity through post-transcriptional mechanisms involving polyadenylation.