Author

Mary P Leatham-Jensen

University of North Carolina at Chapel HillORCID 0000-0002-6416-021XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3 Genomics· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:Drosophila· 5 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 1

Frequent Co-Authors

Daniel J. McKayiD· 6 shared Robert J. DuronioiD· 4 shared A. Gregory MateraiD· 3 shared Aaron T. CrainiD· 1 shared B Rutledge Smith· 1 shared Benjamin D. McMichaeliD· 1 shared Brian D. StrahliD· 1 shared Christina H HilliD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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6 shared papersGenetics

Daniel J. McKayORCID

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6 papers

Recent·Most cited

Histone H3 availability is more important for development than H3.2 versus H3.3 subtype identity

Jeanne-Marie E. McPherson, Claire Sykes, Lucy C. Grossmann, Christina H Hill, Mary P Leatham-Jensen, Robert J. Duronio, D A McKay

This study shows that availability of histone H3 is more critical for development than the specific subtype (H3.2 vs H3.3) in Drosophila.

bioRxiv · Feb 10, 2026 · PreprintGenetics

Dual roles of histone H3 lysine-4 in antagonizing Polycomb group function and promoting target gene expression

Cyril S. Anyetei‐Anum, Mary P Leatham-Jensen, Geoffrey Fox, B Rutledge Smith, Krzysztof Krajewski, Brian D. Strahl, Jill M. Dowen, A. Gregory Matera, Robert J. Duronio, Daniel J. McKay

The paper shows that H3.2K4 antagonizes Polycomb group activity and promotes target gene expression in vivo.

bioRxiv · Jun 25, 2024 · PreprintGenetics

Redesigning the Drosophila histone gene cluster: An improved genetic platform for spatiotemporal manipulation of histone function

Aaron T. Crain, Markus Nevil, Mary P Leatham-Jensen, Katherine B Reeves, A. Gregory Matera, Daniel J. McKay, Robert J. Duronio

The paper develops a new genetic platform in Drosophila to improve spatiotemporal manipulation of histone function through CRISPR and synthetic gene arrays.

bioRxiv · Apr 25, 2024 · PreprintGenetics

The SWI/SNF nucleosome remodeler constrains enhancer activity during Drosophila wing development

Matthew J. Niederhuber, Mary P Leatham-Jensen, Daniel J. McKay

This study shows that the Drosophila BAP complex, a SWI/SNF remodeler, constrains enhancer activity during wing development, preventing ectopic sensory structures and hyperactivation of the Delta gene.

Genetics · Nov 9, 2023Peer-reviewedGenomics

Distinct roles for canonical and variant histone H3 lysine 36 in Polycomb silencing

Harmony R. Salzler, Vasudha Vandadi, Benjamin D. McMichael, John C. Brown, Sally A. Boerma, Mary P Leatham-Jensen, Kirsten M. Adams, Michael P. Meers, Jeremy M. Simon, Robert J. Duronio, Daniel J. McKay, A. Gregory Matera

The paper shows that H3.2 and H3.3 K36 residues have distinct roles in maintaining Polycomb silencing of Hox genes through different mechanisms, enabling development.

Science Advances · Mar 1, 2023Peer-reviewedGenomics

Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responses

Christopher M. Uyehara, Mary P Leatham-Jensen, Daniel J. McKay

The paper investigates how EcR mediates tissue-specific ecdysone responses in Drosophila, finding that EcR functions both repressively and activating, binds tissue-specifically, and does not control chromatin accessibility.

Proceedings of the National Academy of Sciences · Sep 26, 2022Peer-reviewedDevelopmental Biology