Brian P O'Rourke

SureQuant IS-PRM Enables Cross-Species Targeted Quantification of Retinoid Metabolism and Signaling Proteins in the Heart

The paper develops a targeted proteomics method to quantify retinoid metabolism and signaling proteins across species and tissues, revealing tissue-specific networks and developmental changes in the heart.

Formate reduces ischemic injury in the male heart by increasing protein S-nitrosation

This study shows formate reduces ischemic injury in male hearts by increasing protein S-nitrosation and preserving BH4 levels through a NOS-dependent mechanism.

Inhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression

This study investigates the effects of p38 MAPK inhibition on cardiac remodeling in a guinea pig HF model, finding that SB203580 treatment protects cardiac function and phosphoproteome integrity.

Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease

Myocardial BDNF regulates cardiac bioenergetics through the transcription factor Yin Yang 1

This study shows that myocardial BDNF signaling via YY1 regulates cardiac bioenergetics and mitochondrial function during stress.

Mitochondrial DNA Copy Number (mtDNA-CN) Can Influence Mortality and Cardiovascular Disease via Methylation of Nuclear DNA CpGs

This study identifies CpGs associated with mtDNA-CN and shows they influence disease-related phenotypes through nDNA methylation and gene expression changes.

Mitochondrial DNA Copy Number and Incident Atrial Fibrillation

This study investigates the association between mitochondrial DNA copy number and risk of atrial fibrillation in three cohorts, finding an inverse relationship after adjustment for traditional risk factors.