Claudia I. Semprich

Multimodal Hypersampling of the adult human heart resolves tissue-specific cell states and disease-associated variants

This paper creates a detailed heart atlas using multimodal data to identify cell states and disease-associated genetic variants in specific heart regions.

Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency

The paper investigates the chromosomal contacts of poised enhancers during the transition from naive to primed human pluripotency, revealing their dynamics and functional significance.

Single Cell Integration Characterises Metaplasia in Inflammatory Intestinal Diseases

The paper integrates single-cell RNA-seq datasets across the GI tract to identify epithelial metaplasia in inflammatory diseases, showing its role in inflammation through immune cell interactions.

Developmental Dynamics of Human Cardiogenesis: A multi-omic reference and its disruption in Trisomy 21

This study develops a multi-omic reference of human cardiac development and identifies disruptions in Trisomy 21 hearts.

A human developing heart atlas reveals cardiovascular cell diversity for in vitro model benchmarking

The paper creates a high-resolution human developing heart atlas using single-cell and spatial transcriptomics, identifies new cell types, and benchmarks in vitro models.

Spatially resolved multiomics of human cardiac niches

This paper uses spatial transcriptomics and single-cell data to identify cellular niches in the human heart, revealing new insights into cardiac function and potential drug targets.

ERK1/2 signalling dynamics promote neural differentiation by regulating the polycomb repressive complex

The paper shows that ERK1/2 signaling decline promotes neural differentiation by reducing polycomb repressive complex occupancy at neural genes, increasing chromatin accessibility, and enabling transcription.