Author

Sam N. Barnett

Imperial College LondonORCID 0000-0002-8968-4319Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:scRNA-seq· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Assay:spatial transcriptomics· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:fine-mapping· 2

Frequent Co-Authors

Krzysztof PolańskiiD· 3 shared Sarah Amalia TeichmanniD· 3 shared Anna Wilbrey-ClarkiD· 2 shared Antonio M. A. MirandaiD· 2 shared Claudia I. SemprichiD· 2 shared James J. CranleyiD· 2 shared John Henry DarkiD· 2 shared Kazumasa KanemaruiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Krzysztof PolańskiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multimodal Hypersampling of the adult human heart resolves tissue-specific cell states and disease-associated variants

James J. Cranley, Lukáš Mach, Takahiro Jimba, Kazumasa Kanemaru, Jing Zhao, Shani Perera, Yasemin-Xiomara Zurke, Simon Koplev, Sam N. Barnett, Lu Wang, Kenny Roberts, Rakeshlal Kapuge, Laura Richardson, Krzysztof Polański, Claudia I. Semprich, , Sarah Amalia Teichmann

This paper creates a detailed heart atlas using multimodal data to identify cell states and disease-associated genetic variants in specific heart regions.

bioRxiv · Jun 17, 2026 · PreprintCell Biology

KLF6 in Pulmonary Hypertension: The Dual Role of Friend and Foe

Rehab Salah Saleh Alharbi, Merve Keleş, Nadia J. Fernandes, Hannah Maude, Adam Fellows, Richard Dafydd Williams, Chien-Nien Chen, Nathalie Lambie, Nik Matthews, May Al‐Sahaf, Sam N. Barnett, Minzhe Guo, Lan Zhao, Allan Lawrie, Jeffrey A. Whitsett, , Beata Wójciak‐Stothard

This study identifies KLF6 as a key driver of endothelial dysfunction in pulmonary arterial hypertension, showing its role in promoting vascular remodelling and angioproliferative lesions.

Communications Biology · Jun 15, 2026Peer-reviewedCell Biology

Spatially resolved multiomics of human cardiac niches

Kazumasa Kanemaru, James J. Cranley, Daniele Muraro, Antonio M. A. Miranda, Siew Yen Ho, Anna Wilbrey-Clark, J. Patrick Pett, Krzysztof Polański, Laura Richardson, Monika Litviňuková, Natsuhiko Kumasaka, Yue Qin, Zuzanna Jablonska, Claudia I. Semprich, Lukáš Mach, , Sarah Amalia Teichmann

This paper uses spatial transcriptomics and single-cell data to identify cellular niches in the human heart, revealing new insights into cardiac function and potential drug targets.

Nature · Jul 12, 2023Peer-reviewedGenomics

Mapping interindividual dynamics of innate immune response at single-cell resolution

Natsuhiko Kumasaka, Raghd Rostom, Ni Huang, Krzysztof Polański, Kerstin B. Meyer, Sharad R. Patel, Rachel Boyd, Céline Gomez, Sam N. Barnett, Nikolaos I. Panousis, Jeremy Schwartzentruber, Maya Ghoussaini, Paul Lyons, Fernando J. Calero‐Nieto, Berthold Göttgens, , Sarah Amalia Teichmann

The paper develops GASPACHO to identify dynamic eQTLs in antiviral responses using single-cell RNA-seq, uncovering thousands of eQTLs and linking them to disease risk loci.

Nature Genetics · Jun 1, 2023Peer-reviewedGenetics