Vicki Metzis

The paper identifies temporally distinct CDX-driven regionalisation events that preconfigure vagal and trunk neural crest identities in mouse embryos.

The paper identifies a dual enhancer-silencer element at the Cdx2 locus that controls transient Cdx2 expression during posterior body formation in mice.

The paper shows that gene regulatory network structure influences boundary precision in tissue patterning by modulating stochastic fluctuations, not reducing noise.

The paper shows that Sox2 levels determine how WNT signaling affects epiblast progenitors, influencing pluripotency and mesodermal differentiation through changes in chromatin occupancy and regulatory element selection.

The paper shows that ERK1/2 signaling decline promotes neural differentiation by reducing polycomb repressive complex occupancy at neural genes, increasing chromatin accessibility, and enabling transcription.

The paper challenges the established model of neural induction by showing that cells commit to anterior or posterior regional identities before acquiring neural identity.