Rogger P. Carmen‐Orozco

This study shows Ptbp1 is not required for retinal neurogenesis or cell fate specification, contradicting prior claims of its role as a master regulator.

The paper identifies conserved and species-specific aging mechanisms in retinal cells across zebrafish, mice, and humans using single-cell multi-omics analyses.

This study shows that elevated nuclear TDP-43 causes species-specific exon skipping, which differs from exon skipping seen in TDP-43 loss-of-function, highlighting the need for careful interpretation of TDP-43 overexpression models.

This paper introduces SLED, a splicing-based method to control gene expression in specific cell types, demonstrating its utility in targeting neurons, photoreceptors, and cancer cells.