Pierre-Jacques Hamard

Loss of extracellular matrix-integrin signaling switches off YAP/TEAD and lets prostate adenocarcinoma organoids turn neuroendocrine; LATS inhibition reverses it, and combined YAP, NOTCH and AR inhibition fully reprograms them.

The paper integrates single-cell multiomics and CRISPR screening in prostate cancer organoids to reveal lineage-specific dependencies and heterogeneity effects on gene essentiality.

The paper shows that TAD hierarchy restricts LTR activation, and its loss in cancer allows LTRs to act as alternative promoters, driving oncogene activation and transcriptional diversity.

The paper identifies a sequential transcriptional cascade in the thalamo-cortical circuit that enables memory stabilization over time.

This study identifies a nucleosome switch that primes Hepatitis B Virus infection by driving X gene transcription and shows that CBL137 inhibits this process.

This study identifies a pathogenic subpopulation of glioma-associated macrophages (mGAMs) linked to glioma progression through GRN analysis and functional validation.

This study identifies RXR signaling as a mediator of lipid metabolism in leptomeningeal metastatic cancer cells, revealing a potential therapeutic target.

This study shows mechanical confinement drives phenotype switching in melanoma via chromatin remodeling mediated by HMGB2.