Miranda V. Hunter

Restraint of melanoma progression by cells in the local skin environment

The paper shows that keratinocyte EMT-like transformation in melanoma reduces tumor invasion and improves survival through altered cell-cell interactions.

Identifying in vivo genetic dependencies of melanocyte and melanoma development

This study uses a zebrafish model to identify genetic dependencies in melanocyte and melanoma development, revealing that gene loss can paradoxically promote aggressive phenotypes.

The lipid droplet protein DHRS3 is a regulator of melanoma cell state

The paper identifies DHRS3 as a lipid droplet protein that regulates melanoma cell state by modulating retinoid signaling.

Real time imaging reveals a role for macrophage protrusive motility in melanoma invasion

This study uses real-time imaging in zebrafish to show that macrophage protrusive motility, regulated by Rac2, influences melanoma invasion.

Mechanical confinement governs phenotypic plasticity in melanoma

This study shows mechanical confinement drives phenotype switching in melanoma via chromatin remodeling mediated by HMGB2.

BayesTME: A unified statistical framework for spatial transcriptomics

BayesTME is a Bayesian method for spatial transcriptomics that unifies analysis goals, outperforms existing methods, and identifies spatial transcriptional programs in human and zebrafish melanoma tissues.