Stuart M. Haslam

Bovine H5N1 influenza viruses have adapted to more efficiently use receptors abundant in cattle

This study shows bovine H5N1 influenza viruses have adapted to efficiently use NeuGc receptors in cattle, enhancing replication without significantly altering zoonotic risk.

Mutations in severe human H5N1 cases facilitate evasion from human mucus and antivirals

This study examines mutations in H5N1 influenza virus HA that affect receptor binding and antiviral susceptibility, finding reduced sialic acid binding correlates with mucus evasion and antiviral resistance.

The canine respiratory epithelium is a permissive ecosystem for influenza interspecies transmission and emergence

This study shows that the canine respiratory tract supports influenza A virus replication and could facilitate interspecies transmission and emergence of new IAVs.

Arthritis-Associated Inflammation Remodels Colonic O-Glycosylation

This study shows arthritis-associated inflammation reduces colonic mucin fucosylation, linking intestinal inflammation to fibroblast-driven microenvironment changes.

H3N2 influenza virus tropism shifts to glycan receptors on tracheal ciliated cells

The paper shows H3N2 influenza viruses preferentially bind to tracheal ciliated cells due to specific glycan receptors.

The cow udder is a potential coinfection site for influenza A viruses

The study shows cow mammary gland cells can support replication of multiple IAV strains and are susceptible to co-infection with human and avian IAVs, suggesting the udder may act as a site for viral reassortment.

Cell-specific Bioorthogonal Tagging of Glycoproteins

The paper introduces BOCTAG, a method to label glycoproteins in specific cell types within mixed cultures, enabling analysis of cell-specific glycosylation.

Proteome-wide prediction of bacterial carbohydrate-binding proteins as a tool for understanding commensal and pathogen colonisation of the vaginal microbiome

The paper predicts bacterial carbohydrate-binding proteins (lectins) across genomes to explore their role in vaginal microbiome colonization and pathogenicity.

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

This paper introduces GalNAzMe, a monosaccharide probe that selectively labels O-GalNAc glycosylation in living cells, enabling detailed study of this cancer-relevant modification.