Author

Leah F. Rosin

National Institutes of HealthORCID 0000-0002-2489-4016Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:statistical model· 3 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1

Frequent Co-Authors

Elissa P. LeiiD· 4 shared Clio B. HockensiD· 2 shared Ines Anna DrinnenbergiD· 2 shared Yang CheniD· 2 shared Chen-Yu Liu· 1 shared Dahong CheniD· 1 shared Dai TsuchiyaiD· 1 shared Duílio Mazzoni Zerbinato de Andrade SilvaiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersGenomics

Elissa P. LeiORCID

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Author profile →

6 papers

Recent·Most cited

Programmed meiotic errors facilitate dichotomous sperm production in the silkworm, Bombyx mori

Leif Benner, Makenzie Richmond, Youbin Xiang, LingSze Lee, Clio B. Hockens, Tianwei Li, Zulin Yu, Dai Tsuchiya, Shengping Huang, Eelco C. Tromer, R. Scott Hawley, Leah F. Rosin

This study identifies molecular differences in meiosis between eupyrene and apyrene sperm production in silkworms, showing that Sxl facilitates error-prone meiosis for apyrene sperm.

Proceedings of the National Academy of Sciences · Feb 25, 2026Peer-reviewedGenetics

Unique territorial and compartmental organization of chromosomes in the holocentric silkworm

José Gil, Emily Navarrete, Clio B. Hockens, Neil Chowdhury, Sameer Abraham, Gaetan Cornilleau, Elissa P. Lei, Julien Mozziconacci, Edward J. Banigan, Leah F. Rosin, Leonid A. Mirny, Héloïse Muller, Ines Anna Drinnenberg

The paper discovers a novel chromatin folding structure, compartment S, in the silkworm Bombyx mori using Hi-C, showing unique loop extrusion and contact patterns.

The EMBO Journal · Feb 2, 2026Peer-reviewedGenomics

An egg sabotaging mechanism drives non-Mendelian transmission in mice

Frances E. Clark, Naomi L Greenberg, Duílio Mazzoni Zerbinato de Andrade Silva, Emily Trimm, Morgan Skinner, R. Zaak Walton, Leah F. Rosin, Michael A. Lampson, Takashi Akera

The paper shows that the selfish element R2d2 in mice uses a hybrid mechanism in female meiosis to distort transmission by causing aneuploidy in the egg, leading to increased transmission of R2d2.

Current Biology · Jul 26, 2024Peer-reviewedGenetics

Dosage compensation in Bombyx mori is achieved by partial repression of both Z chromosomes in males

Leah F. Rosin, Dahong Chen, Yang Chen, Elissa P. Lei

This paper visualizes dosage compensation in Bombyx mori males by showing both Z chromosomes are partially repressed, supporting convergent evolution with C. elegans.

Proceedings of the National Academy of Sciences · Mar 3, 2022Peer-reviewedGenetics

Oligopaint DNA FISH as a tool for investigating meiotic chromosome dynamics in the silkworm, Bombyx mori

Leah F. Rosin, Jose Gil, Ines Anna Drinnenberg, Elissa P. Lei

The paper uses Oligopaint FISH to study meiotic chromosome pairing and compaction in Bombyx mori, showing robust pairing in both sexes and similarities to C. elegans bivalent formation.

PLoS Genetics · Jul 28, 2021Peer-reviewedGenetics

M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity

Indira Bag, Shue Chen, Leah F. Rosin, Yang Chen, Chen-Yu Liu, Guo-Yun Yu, Elissa P. Lei

This study identifies M1BP's role in activating transcription at TAD borders and enhancing chromatin insulator activity through its interaction with CP190.

Nature Communications · Jul 7, 2021Peer-reviewedGenomics