Emily Trimm

A stem cell-derived human vein-to-artery endothelial conversion model mirrors angiogenesis-derived embryonic arteries; VEGF plus PI3K inhibition alone yields 92% DLL4+CXCR4+ endothelium by 48 hours.

The paper uses Perturb-seq in mice to identify genes that promote collateral artery formation by comparing gene expression between guinea pigs and mice.

The paper shows that the selfish element R2d2 in mice uses a hybrid mechanism in female meiosis to distort transmission by causing aneuploidy in the egg, leading to increased transmission of R2d2.

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.

This study shows that overexpressing Dach1 in endothelial cells extends coronary arteries and improves heart function after myocardial infarction in mice.