Synthetic inhibitors of pregnancy-associated plasma protein-A regulate IGF-1 signaling in vitro and in vivo
Anna Kertisová, Shang‐Wu Shih, Nicholas S. Kirk, Jan Pícha, Agáta Rücklová, Jaroslav Kozák, Karolína Mrzílková, Marta Lubos, Eva Tloušťová, Miloš Buděšı́nský, Cunming Duan, Jiřı́ Jiráček, Irena Selicharová
This study develops synthetic PAPP-A inhibitors that modulate IGF signaling in vitro and in vivo, showing efficacy comparable to natural inhibitors.
bioRxiv · Oct 2, 2026 · PreprintBiochemistry