Benedict James Kolber

The paper develops a 3D agent-based model of the bilateral central amygdala to predict pain outcomes by integrating neuronal data from CGRPR and PKCδ cells.

This study identifies CGRPR-expressing neurons in the central amygdala as key players in pain hypersensitivity, showing their role in both injury-induced and spontaneous pain responses.

This study investigates the role of amygdala CGRP receptors in persistent bladder pain in mice, showing that right CeA inhibition reduces pain-like behavior while left inhibition sustains hypersensitivity.

This study investigates the role of CeA CGRP in neuropathic pain, finding that it modulates cold sensitivity differently based on injury type and hemisphere.

This paper characterizes the cyanobacterial metabolite Veraguamide E, showing it binds the sigma-2 receptor with high affinity, modulates calcium signaling in neurons, and lacks cytotoxicity.

The paper identifies a right-biased neuronal population in vagus nerves that expresses genes related to digestive signaling and may contribute to asymmetric reward processing.

This paper develops a high-content screening platform using hiPSC-derived nociceptors on micro-electrode arrays to identify analgesic drugs with reliable assay performance and functional target validation.

This paper isolates and evaluates three veraguamide analogs from a marine cyanobacterium, finding one shows cytotoxicity against triple-negative breast cancer cells and affinity for the sigma2 receptor.

This paper identifies FEM-1689 as a σ2R/TMEM97 ligand that alleviates neuropathic pain by inhibiting the integrated stress response in mice and human sensory neurons.

The paper identifies a parabrachial-to-amygdala circuit mediated by CGRP that drives hemispheric lateralization of visceral pain processing in mice.