Filip Krag Knop

This study identifies FGF21 as a specific ethanol-induced hormone through proteomic profiling of acute alcohol intoxication in humans.

The paper identifies a loss-of-function variant in GFRAL associated with increased alcohol consumption in humans and shows GDF15 reduces alcohol drinking in mice.

This paper shows that long-term cytokine exposure impairs alpha-cell glucagon secretion in human islet microtissues, which is partially restored by dual incretin receptor agonists.

This study investigates the functional, protective, and transcriptomic effects of GIP on cytokine-exposed human pancreatic islets and EndoC-βH5 cells, finding CaMK2-dependent insulinotropic effects but limited cytoprotection and transcriptomic modulation.