Author

David William Howells

University of TasmaniaORCID 0000-0002-2512-7724Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:imaging· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Brad A. SutherlandiD· 3 shared Gary P. MorrisiD· 3 shared Jo‐Maree CourtneyiD· 2 shared Lachlan S. BrowniD· 2 shared Alastair Mitchell BuchaniD· 1 shared Alexandra Bannach‐BrowniD· 1 shared Alison Jane CantyiD· 1 shared Anna Elizabeth KingiD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersNeuroscience

Brad A. SutherlandORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rapamycin Treatment Reduces Brain Pericyte Constriction in Ischemic Stroke

Daniel J. Beard, Lachlan S. Brown, Gary P. Morris, Yvonne Couch, Bryan A. Adriaanse, Christina Simoglou Karali, Anna M. Schneider, David William Howells, Zoran B Redzic, Brad A. Sutherland, Alastair Mitchell Buchan

This study shows rapamycin reduces brain pericyte contraction during ischemia but not viability, improving capillary diameter and openness after stroke.

Translational Stroke Research · Sep 27, 2024Peer-reviewedNeuroscience

Microglia associations with brain pericytes and the vasculature are reduced in Alzheimer's disease

Gary P. Morris, Catherine G. Foster, Jo‐Maree Courtney, Jessica Marie Collins, Jake M. Cashion, Lachlan S. Brown, David William Howells, Gabriele Carmine DeLuca, Alison Jane Canty, Anna Elizabeth King, Jenna M. Ziebell, Brad A. Sutherland

The paper identifies a subpopulation of microglia associated with pericytes in the brain and shows this population is reduced in Alzheimer's disease in the superior frontal gyrus.

Glia · Mar 30, 2023Peer-reviewedNeuroscience

An automated approach to improve the speed and accuracy of pericyte and microglia quantification in whole mouse brain sections

Jo‐Maree Courtney, Gary P. Morris, Elise M Cleary, David William Howells, Brad A. Sutherland

The paper presents an automated method using QuPath to quantify microglia and pericytes in whole mouse brain sections, showing regional differences in cell proportions.

eNeuro · Oct 12, 2021Peer-reviewedNeuroscience

Estimating the statistical performance of different approaches to meta-analysis of data from animal studies in identifying the impact of aspects of study design

Qianying Wang, Jing Liao, Kaitlyn Hair, Alexandra Bannach‐Brown, Zsanett Bahor, Gillian L. Currie, Sarah McCann, David William Howells, Emily S. Sena, Malcolm Robert Macleod

This paper compares statistical methods for meta-analysis of animal studies, finding that normalized mean difference (NMD) has higher power than standardized mean difference (SMD), and meta-regression outperforms stratified meta-analysis.

bioRxiv · Jan 30, 2018 · PreprintBioinformatics