Polina Shichkova

This paper develops an automated sample preparation platform for bottom-up proteomics, demonstrating improved reproducibility, throughput, and suitability for drug development.

This study develops a multiscale electro-metabolic model of a rat neocortex to show that middle cortical layers are more vulnerable to energy impairment with age.

The paper develops a molecular model of the aging brain's metabolic system, identifies key disruptions, and proposes interventions to restore metabolic flexibility and neuronal function.

The paper predicts SNPs affecting drug-protein binding affinities using genomic and drug interaction data, estimating that individuals carry ~6 SNPs impacting ~5 FDA-approved drugs.