Darshan Mandge

Do we understand orientation selectivity? A simulation study

This study shows that current mechanisms for orientation selectivity in the visual cortex fail in realistic models, suggesting homeostatic plasticity may be necessary.

A Detailed Model for Understanding the Human Neocortex

This study builds a detailed computational model of the human neocortex and compares it to a rat model, revealing differences in cell density, branching complexity, and synaptic connectivity.

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation

The paper presents a large-scale biophysically detailed model of somatosensory cortex to simulate and validate cortical dynamics and experimental results.

A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers

This study develops a multiscale electro-metabolic model of a rat neocortex to show that middle cortical layers are more vulnerable to energy impairment with age.

A universal workflow for creation, validation and generalization of detailed neuronal models

The paper introduces a workflow for creating and validating detailed neuronal models using rat somatosensory cortex data, showing it can generate models with varied responses.

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

This paper introduces a multi-modal fitting framework combining patch-clamp and HD-MEA data to build more accurate multicompartment neuron models.