Thorsten Mosler

This paper develops R4VPs, PROTAC-like compounds that induce ferroptosis in aggressive cancers while sparing normal cells, showing efficacy against therapy-resistant melanoma and sarcomas.

ProxiCapture identifies context-dependent CRBN interactors of molecular glues across diverse cell types and tissues, revealing a comprehensive atlas of pomalidomide targets.

This paper constructs a comprehensive annotated dataset of human E3 ligases and uses a hierarchical classification framework to analyze their functional and structural relationships.

The paper identifies MAEA as a critical regulator of DNA repair and replication, with loss of function causing developmental delay and neurodevelopmental deficits.

The paper investigates how Mga2 converts membrane physical cues into biochemical outputs via ubiquitylation, revealing a signal amplification mechanism involving E3 ligase autoubiquitylation.

This study shows that the RNF4 ligand CCW16 induces ferroptosis in AML cells through a RNF4-independent mechanism by causing covalent protein modifications and upregulating ferroptosis markers.

This study identifies TRIM28's role in pre-mRNA splicing through phosphorylation and SUMOylation interactions with USP39, showing its impact on alternative splicing patterns.

This study shows that disrupting BAP1, an epigenetic regulator, causes chromatin remodeling and leads to breast cancer stem cell-like properties and altered glycosylation.