William Harrison Hicks

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

The paper develops a platform to trace 30 nitrogen isotope-labeled metabolites, revealing cell state-specific pyrimidine synthesis pathway preferences in primitive and differentiated cells.

Semi-automated computational assessment of cancer organoid viability using rapid live-cell microscopy

This paper develops a method to assess cancer organoid viability using rapid imaging and a fragmentation algorithm, finding significant correlations between SSD scores and traditional viability markers.