Marc Flajolet

This study profiles cell-type specific changes in human entorhinal cortex at early Alzheimer's disease stages, identifying dysregulation of Reelin signaling and downregulation of NPTX2 and CBLN4.

This study shows that operant training with highly palatable food alters translating mRNA in NAc D2 neurons and that Ncdn downregulation modulates satiety-sensitive feeding behavior.

The paper identifies DEK as a driver of tau pathology in Alzheimer's disease vulnerable neurons using in silico modeling and experimental validation.

This study shows that HCN2 in cholinergic interneurons of the nucleus accumbens enhances dopamine signaling in response to rewarding stimuli.

This study identifies GSAP's role in Alzheimer's disease by showing it regulates mitochondrial function through the MAM and lipid homeostasis, with a SNP linked to increased AD risk.

This study shows GSAP regulates amyloid beta production by modulating APP trafficking, specifically by affecting the immobile vesicle pool associated with amyloidogenic processing.

This study identifies a functional gene module associated with selective neuronal vulnerability in Alzheimer’s disease using integrated molecular and genetic data from mice and humans.