Fernando Moreira Simabuco

S6K1 and S6K2 regulate homologous recombination DNA repair through control of BRCA1 protein stability

This study shows that S6K1 and S6K2 regulate BRCA1 stability and HR repair, with their double knockout increasing DNA damage sensitivity and genomic instability.

Characterization and therapeutic suppression of KEAP1-NRF2-driven resistance to KRAS inhibitors in pancreatic and lung cancer

This study identifies KEAP1 loss as a resistance mechanism to KRAS inhibitors in pancreatic and lung cancer and shows that combining glutamine inhibition with KRAS inhibitors can overcome this resistance.

Characterization of the interaction between SARS-CoV-2 Membrane Protein and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target

The paper investigates the interaction between SARS-CoV-2 Membrane Protein and PCNA, showing cytoplasmic translocation of PCNA and its potential as a therapeutic target.

POMC-specific knockdown of Tril reduces body adiposity and increases hypothalamic leptin responsiveness

The paper identifies Tril as a mediator of high-fat diet effects in POMC neurons, showing that its knockdown reduces adiposity and increases leptin responsiveness in the hypothalamus.