Michael Boyce

Dynamic O-GlcNAcylation of Sec23-interacting protein regulates COPII function

This study shows that O-GlcNAcylation of Sec23IP dynamically regulates its interaction with Sec31A, modulating COPII assembly and function during protein transport.

Discovery of cell-active small molecule inhibitors of UDP-galactose 4'-epimerase

This paper identifies disulfiram as a cell-active inhibitor of human GALE through high-throughput screening, showing its effects on glycosylation and mucin biosynthesis.

Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylation

This study shows that KLHL3 and WNK kinases are regulated by O-GlcNAcylation, affecting osmolarity control and ferroptosis, with implications for blood pressure and neuronal health.

Dynamic regulation of Sec24C by phosphorylation and O-GlcNAcylation during cell cycle progression

This study identifies phosphorylation and O-GlcNAcylation of Sec24C as mechanisms regulating its mitotic dispersal and potential role in equal partitioning of endomembranes.

Dynamic regulation of the COPII interactome and collagen trafficking by site-specific glycosylation of Sec24D

The paper shows that O-GlcNAcylation of Sec24D regulates collagen trafficking by modulating its interactome and interaction with myoferlin in human cells and zebrafish.