S6K1 and S6K2 regulate homologous recombination DNA repair through control of BRCA1 protein stability
Mariana Marcela Góis, Lais Bonafe, L O Silva…·Fernando Moreira Simabuco
This study shows that S6K1 and S6K2 regulate BRCA1 stability and HR repair, with their double knockout increasing DNA damage sensitivity and genomic instability.