Author

Lesley S. Chaboub

University of PennsylvaniaORCID 0000-0002-2773-8027Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Connor HoganiD· 1 shared Desi C. AlexanderiD· 1 shared Drew WeissmaniD· 1 shared Greg DonahueiD· 1 shared Hong Wei XuiD· 1 shared Honghong Sun· 1 shared Houping NiiD· 1 shared Jenna Muscat-Rivera· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Connor HoganORCID

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2 papers

Recent·Most cited

NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedJan 9, 2026

ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration

Naemeh Pourshafie, Desi C. Alexander, Hong Wei Xu…·Shelley L. Berger

This study shows that increasing ACSS2 levels protects neurons from age-related and tau-induced decline by enhancing synaptic and longevity gene expression.

4 citationstop 1%

mousebulk RNA-seq

𝕏 PostBluesky

BioengineeringbioRxivPreprintOct 17, 2025

Anionic lipids modulate mRNA-lipid nanoparticle immunogenicity and confer protection in a mouse model of multiple sclerosis

Jilian R. Melamed, Jenna Muscat-Rivera, Michael Kegel…·Drew Weissman

This study shows that anionic lipids in mRNA-LNPs can modulate immune responses, reducing inflammation and disease in a multiple sclerosis mouse model.

5 citations

mousebulk RNA-seq

𝕏 PostBluesky