Author

Martin Thelen

University of CologneORCID 0000-0002-2785-9726Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Frank KlawonniD· 2 shared Milita DarguzyteiD· 2 shared Renata StripeckeiD· 2 shared A. Ernst· 1 shared Andreas SchneideriD· 1 shared Anna Christina DragoniD· 1 shared Anna SchmittiD· 1 shared B. Soper· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

Frank KlawonnORCID

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2 papers

Recent·Most cited

Memory T Cells in MHC-Deficient Humanized Mice

Milita Darguzyte, Zhibek Zhumadilova, F. Khan, Masudur Rahman, S Sagar, A. Ernst, Isabel C. Poschke, Jonas Schulte-Schrepping, Elena De-Domenico, Marc Beyer, Dirk Schaudien, Anna Christina Dragon, Britta Eiz‐Vesper, Constantine von Kaisenberg, Frank Klawonn, , Renata Stripecke

This study compares T cell development in humanized mice with and without murine MHC, finding that busulfan conditioning in MHC-deficient mice promotes activated T cells while irradiation favors naive T cells.

bioRxiv · Aug 21, 2026 · PreprintImmunology

T-cell development and activation in humanized mice lacking mouse major histocompatibility complexes

Milita Darguzyte, Philipp Antczak, Daniel Bachurski, Patrick Hoelker, Nima Abedpour, Rahil Gholamipoorfard, Hans Schlößer, Kerstin Wennhold, Martin Thelen, Maria Alejandra Garcia-Marquez, Johannes Koenig, Andreas Schneider, Tobias Braun, Frank Klawonn, Michael Damrat, , Renata Stripecke

This study shows human T-cell development in humanized mice can occur without mouse MHCs and is enhanced by lentiviral delivery of HLA and cytokines.

Cells · Oct 12, 2024Peer-reviewedImmunology