T-cell development and activation in humanized mice lacking mouse major histocompatibility complexes
Milita Darguzyte, Philipp Antczak, Daniel Bachurski, Patrick Hoelker, Nima Abedpour, Rahil Gholamipoorfard, Hans Schlößer, Kerstin Wennhold, Martin Thelen, Maria Alejandra Garcia-Marquez, Johannes Koenig, Andreas Schneider, Tobias Braun, Frank Klawonn, Michael Damrat, , Renata Stripecke
This study shows human T-cell development in humanized mice can occur without mouse MHCs and is enhanced by lentiviral delivery of HLA and cytokines.
Cells · Oct 12, 2024Peer-reviewedImmunology