Author

Patrick Hoelker

University of CologneORCID 0000-0002-9464-7985Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Daniel BachurskiiD· 2 shared Luca D SchreursiD· 2 shared Nima AbedpouriD· 2 shared Phuong‐Hien NguyeniD· 2 shared Rahil GholamipoorfardiD· 2 shared Alexander F. vom SteiniD· 1 shared Amin Mokhlesi· 1 shared An HendrixiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Daniel BachurskiORCID

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Author profile →

3 papers

Recent·Most cited

Tumour-derived factors prime microglia for immune checkpoint-mediated T-cell regulation

Luca D Schreurs, Jessica Barz, Trong-Hieu Nguyen, Jule Schmedding, Liudmila Lobastova, Patrick Hoelker, Tamina Seeger-Nukpezah, J. Lackmann, Jana Caroline Hollenbeck, Christina Ising, Ulf D. Kahlert, Timmer Marco, Roland Goldbrunner, Volker Neuschmelting, Phuong‐Hien Nguyen

This study identifies an early microglial activation program driven by soluble factors from tumors, leading to immune checkpoint regulation and immunosuppression in brain tumors.

bioRxiv · Oct 13, 2026 · PreprintCancer Biology

Single recipient cell tracking of tellurium-labeled extracellular vesicle proteomes (TeLEV) identifies EV-driven immunomodulation

Daniel Bachurski, Rahil Gholamipoorfard, Yong Jia Bu, Patrick Hoelker, Lisa Wessendorf, Hendrik Jestrabek, Luca D Schreurs, David J. Stahl, Amin Mokhlesi, Philipp Gödel, Felix Gaedke, Elias Ranjbari, Selen Seyhan, Ulrike Resch, Luisa Marie Schmidt, , Nima Abedpour

The paper introduces TeLEV, a method to track EV proteomes in immune cells, revealing EV-driven immunomodulation through STAT5-dependent mechanisms.

bioRxiv · Nov 1, 2025 · PreprintCancer Biology

T-cell development and activation in humanized mice lacking mouse major histocompatibility complexes

Milita Darguzyte, Philipp Antczak, Daniel Bachurski, Patrick Hoelker, Nima Abedpour, Rahil Gholamipoorfard, Hans Schlößer, Kerstin Wennhold, Martin Thelen, Maria Alejandra Garcia-Marquez, Johannes Koenig, Andreas Schneider, Tobias Braun, Frank Klawonn, Michael Damrat, , Renata Stripecke

This study shows human T-cell development in humanized mice can occur without mouse MHCs and is enhanced by lentiviral delivery of HLA and cytokines.

Cells · Oct 12, 2024Peer-reviewedImmunology