Hongbo Chi

MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia

This study identifies MOZ and HBO1 as molecular dependencies in NUP98-rearranged AML, showing their inhibition reduces leukemic burden and synergizes with Menin inhibitors.

Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment

This study shows that deleting Regnase-1 in CAR T cells enhances their antitumor activity against osteosarcoma by creating a proinflammatory tumor microenvironment.

Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT

Perturb-DBiT co-sequences spatial transcriptomes and gRNAs on one tissue section, supporting genome-wide in vivo CRISPR screens in FFPE and fresh-frozen tumors across three cancer models.

scMINER: a mutual information-based framework for identifying hidden drivers from single-cell omics data

scMINER identifies hidden drivers and network rewiring in single-cell RNA-seq data using mutual information, outperforming existing methods in clustering and network inference.

Single-cell analysis identifies TCF4 and ID3 as a molecular switch of mammary epithelial stem cell differentiation.

The paper identifies TCF4 and ID3 as key transcription factors driving mammary epithelial stem cell differentiation through single-cell RNA sequencing analysis.