Martin McBride

Osteopontin Mediates Uterine Artery Dysfunction in Hypertensive Pregnancy

This study identifies osteopontin as a mediator of impaired uterine artery remodelling in hypertensive pregnancy, showing its deficiency improves vascular function and fetal growth.

Identification of osteopontin as a positional and functional candidate gene for cardiac hypertrophy in the SHRSP rat

The paper identifies osteopontin (Spp1) as a positional and functional candidate gene for cardiac hypertrophy in SHRSP rats through congenic strain analysis and transcriptome profiling.

Targeting Runx1 protects against heart failure with preserved ejection fraction

This study shows that inhibiting Runx1 protects against heart failure with preserved ejection fraction in mice by improving diastolic function and reducing hypertrophy and pulmonary edema.

Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing

The paper investigates dominance and additivity in mammalian genetics, finding dominance accounts for 25% of heritable variance and reveals novel dominance QTLs and trans-acting effects in gene expression.