Author

Christopher M. Thomas

University of BirminghamORCID 0000-0002-2810-0455Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Thomas C. McLeaniD· 2 shared Brian T. ChaitiD· 1 shared Clara Aicart-RamosiD· 1 shared Clinton A ElgiD· 1 shared David M. LawsoniD· 1 shared David SneddoniD· 1 shared Elizabeth A. CampbelliD· 1 shared Elizabeth Soderling· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Thomas C. McLeanORCID

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Author profile →

3 papers

Recent·Most cited

Molecular switching of a DNA-sliding clamp to a repressor mediates long-range gene silencing

Thomas C. McLean, Francisco de Asís Balaguer, Joshua Chandanani, Christopher M. Thomas, Clara Aicart-Ramos, Sophia Burick, Paul Dominic B. Olinares, Giulia Gobbato, Julia E. A. Mundy, Brian T. Chait, David M. Lawson, Seth Andrew Darst, Elizabeth A. Campbell, Fernando Moreno‐Herrero, Tung B. K. Le

The paper shows that KorB, a DNA-sliding clamp, switches to a repressor role with KorA to mediate long-range gene silencing on plasmid RK2.

Nature Microbiology · Jan 23, 2025Peer-reviewedMicrobiology

Evolution of a Plasmid Regulatory Circuit Ameliorates Plasmid Fitness Cost

Clinton A Elg, Erin Mack, Michael Rolfsmeier, Thomas C McLean, David Sneddon, Olivia Kosterlitz, Elizabeth Soderling, Solana Narum, Paul A Rowley, Jack Sullivan, Christopher M Thomas, Eva M Top

This study shows that inactivating the upf31 gene in a plasmid improves its maintenance in E. coli by altering gene regulation, demonstrating how plasmid evolution can affect host range.

bioRxiv · Feb 5, 2024Microbiology

DeepCDpred: Inter-residue Distance and Contact Predictionfor Improved Prediction of Protein Structure.

Shuangxi Ji, Tuğçe Oruç, Liam Mead, Muhammad Fayyaz ur Rehman, Christopher M. Thomas, Sam Butterworth, Peter J. Winn

This paper introduces DeepCDpred, a method that predicts inter-residue distances and contacts to improve protein structure prediction, showing better results than contact prediction alone.

PLoS ONE · Jan 8, 2019Peer-reviewedBioinformatics