Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit
Alice Gilbert, Xabier Elorza‐Vidal, Armelle Rancillac, Audrey Chagnot, Mervé Yetim, Vincent Hingot, Thomas Deffieux, Anne-Cécile Boulay, Rodrigo Alvear‐Perez, Salvatore Cisternino, Sabrina Martín, Sonia Taïb, A. Gélot, Virginie Mignon, Maryline Favier, , Martine Cohen‐Salmon
This study shows that MLC1 is essential for postnatal development of the gliovascular unit, leading to vascular and fluid clearance defects in a mouse model of megalencephalic leukoencephalopathy.
eLife · Nov 1, 2021Peer-reviewedNeuroscience