Jingjing Wang

Interorganelle competition for linoleic acid underlies steatotic liver pathology

This study identifies CLSTN3B as a driver of MASLD by promoting LD biogenesis and altering lipid partitioning between LDs and mitochondria, leading to mitochondrial dysfunction and oxidative stress.

Hepatocyte-specific CLSTN3B ablation impairs lipid droplet maturation and alleviates diet-induced steatohepatitis in mice

This study shows that CLSTN3B promotes lipid droplet maturation in hepatocytes and that its deletion reduces steatohepatitis in mice, with a positive correlation between CLSTN3B expression and MASLD severity in humans.

Mechanistic basis for protection against fatty liver disease by CIDEB loss-of-function mutations

This study investigates how CIDEB loss-of-function mutations protect against fatty liver disease by enhancing β-oxidation through ATGL and PPARα activation.

Deepurify: a multi-modal deep language model to remove contamination from metagenome-assembled genomes

Deepurify uses a multi-modal deep language model with contrastive learning to improve MAG decontamination by leveraging genomic sequences and taxonomic lineages.