Qiyu Zeng

Interorganelle competition for linoleic acid underlies steatotic liver pathology

This study identifies CLSTN3B as a driver of MASLD by promoting LD biogenesis and altering lipid partitioning between LDs and mitochondria, leading to mitochondrial dysfunction and oxidative stress.

Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity

The paper identifies somatic TYK2 mutations in TILs that enhance anti-cancer immunity and shows their therapeutic potential through mouse models.

Hepatocyte-specific CLSTN3B ablation impairs lipid droplet maturation and alleviates diet-induced steatohepatitis in mice

This study shows that CLSTN3B promotes lipid droplet maturation in hepatocytes and that its deletion reduces steatohepatitis in mice, with a positive correlation between CLSTN3B expression and MASLD severity in humans.

Mechanistic basis for protection against fatty liver disease by CIDEB loss-of-function mutations

This study investigates how CIDEB loss-of-function mutations protect against fatty liver disease by enhancing β-oxidation through ATGL and PPARα activation.

IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration

This study shows that IGFBP2-expressing midlobular hepatocytes contribute to liver homeostasis and regeneration after injury or fasting.