Jakub Gołąb

PolyA tail segmentation improves the stability of the template DNA and increases the translatability of in vitro transcribed mRNA

The paper develops segmented polyA tail designs to improve DNA stability and mRNA translatability, finding that longer segmented tails significantly enhance protein production.

Cellohood: multi-granular discovery of cellular neighborhoods with a permutation-invariant set transformer auto-encoder

Cellohood identifies cellular neighborhoods in spatial transcriptomics data, revealing clinically relevant patterns across multiple granularity levels.

Chemical circularization of in vitro transcribed RNA opens new avenues for circular mRNA design

This paper introduces a chemical method to circularize in vitro transcribed RNA, producing chemically circularized RNAs (chem-circRNAs) with high efficiency and compatibility with modifications.