Author

Diana M. Shih

University of California, Los AngelesORCID 0000-0002-2848-3492Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Aldons Jake LusisiD· 3 shared Brian J. BennettiD· 2 shared Hooman AllayeeiD· 2 shared Adriana Huertas‐Vázquez· 1 shared Alicia SampieriiD· 1 shared Anna C. CalkiniD· 1 shared Blanca Estela Del-Rio-NavarroiD· 1 shared Blanca Estela López-ContrerasiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersGenetics

Aldons Jake LusisORCID

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Author profile →

3 papers

Recent·Most cited

Primary-Level Meta-Analysis of Diversity Outbred Mice Identifies a Fasting Plasma Trimethylamine N-Oxide (TMAO) Locus Modified by Sex and Diet

Kristen J. Sutton, Levi W. Evans, Erik Gertz, Dawson Budke, M. Nazmul Huda, Phoebe Yam, Myungsuk Kim, Jennifer M. Rutkowsky, Diana M. Shih, Jaana Hartiala, Daniel Pomp, Aldons Jake Lusis, Hooman Allayee, Brian J. Bennett

The paper identifies a TMAO locus on mouse chromosome 12 modified by sex and diet through a meta-analysis of 1,482 Diversity Outbred mice.

bioRxiv · Jun 24, 2026 · PreprintGenetics

Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerability

Jenny Yeuk‐Ki Cheng, Michael Cheng, Satyesh K. Sinha, Ingrid Cely, Sharda Charugundla, Maggie Han, Guanglin Zhang, Zhiqiang Zhou, Sasha Gladkikh, In Sook Ahn, Graciel Diamante, Yu-Chen Wang, Zeneng Wang, Brian J. Bennett, Hua “Linda” Cai, , Diana M. Shih

This study shows TMAO affects cell type-specific pathways in mouse aorta, promoting atherosclerotic plaque instability by increasing apoptosis and reducing ECM formation.

Arteriosclerosis Thrombosis and Vascular Biology · Aug 14, 2025Peer-reviewedPhysiology

A functional variant of the SIDT2 gene involved in cholesterol transport is associated with HDL-C levels and premature coronary artery disease.

Paola León‐Mimila, Hugo Villamil‐Ramírez, Luis R. Macías Kauffer, Leonor Jacobo‐Albavera, Blanca Estela López-Contreras, Rosalinda Posadas‐Sánchez, Carlos Posadas‐Romero, Sandra Romero‐Hidalgo, Sofía Morán‐Ramos, Mayra Domínguez‐Pérez, Marisol Olivares-Arévalo, Priscilla López-Montoya, Roberto Nieto-Guerra, Víctor Acuña-Alonzo, Gastón Macín Pérez, , Samuel Canizales‐Quinteros

Arteriosclerosis Thrombosis and Vascular Biology · Jul 8, 2021Peer-reviewedGenetic & Genomic Medicine