In Sook Ahn

Relative contribution of gonads and sex chromosomes to sex differences in cell-type gene expression in the mouse medial septum and sex-biased disease risk

The paper investigates the relative impact of gonads and sex chromosomes on sex differences in gene expression in the mouse medial septum and links these differences to sex-biased human diseases.

Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerability

This study shows TMAO affects cell type-specific pathways in mouse aorta, promoting atherosclerotic plaque instability by increasing apoptosis and reducing ECM formation.

Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis

This study identifies Prdm16 and Vcam1 as regulators of postnatal radial glia disappearance and the termination of cortical neurogenesis.

Thyroid Hormone T4 Mitigates Traumatic Brain Injury by Dynamically Remodeling Cell Type Specific Genes, Pathways, and Networks in Hippocampus and Frontal Cortex

This study shows T4 treatment alters cell-type specific genes, pathways, and networks in hippocampus and frontal cortex after mTBI, reversing mTBI-affected genes and pathways.

Hypothalamic estrogen receptor alpha mediates key side effects of tamoxifen therapy in mice

This study identifies hypothalamic estrogen receptor alpha as a mediator of tamoxifen-induced side effects in mice through single-cell RNA sequencing and genetic knockout experiments.

Gene Networks and Pathways for Plasma Lipid Traits via Multi-tissue Multi-omics Systems Analysis

This study identifies gene networks and pathways associated with plasma lipid traits using multi-tissue multi-omics analysis, revealing both known and novel regulators of lipid metabolism.

Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to High Fructose Consumption in Mice

This study shows that gut microbiota differences between mouse strains contribute to varied metabolic responses to high fructose consumption, with Akkermansia playing a key protective role.

Single Cell Molecular Alterations Reveal Pathogenesis and Targets of Concussive Brain Injury

This study uses single-cell sequencing to identify hippocampal cell types and genes vulnerable to concussive TBI, revealing pathogenic mechanisms and therapeutic targets.