Graciel Diamante

The paper investigates the relative impact of gonads and sex chromosomes on sex differences in gene expression in the mouse medial septum and links these differences to sex-biased human diseases.

This study shows TMAO affects cell type-specific pathways in mouse aorta, promoting atherosclerotic plaque instability by increasing apoptosis and reducing ECM formation.

This study shows that reducing Glo1 in mice causes age- and sex-dependent metabolic issues like obesity and altered lipid metabolism without significant changes in AGEs.

This study identifies Prdm16 and Vcam1 as regulators of postnatal radial glia disappearance and the termination of cortical neurogenesis.

This study shows T4 treatment alters cell-type specific genes, pathways, and networks in hippocampus and frontal cortex after mTBI, reversing mTBI-affected genes and pathways.

This study identifies oleoylethanolamide (OEA) as a key mediator by which Akkermansia muciniphila alleviates fructose-induced metabolic syndrome through gut microbiota and gut-hypothalamus axis modulation.

PharmOmics predicts drug repurposing by analyzing species- and tissue-specific drug signatures from genomic data and validates predictions in mice.

This study identifies hypothalamic estrogen receptor alpha as a mediator of tamoxifen-induced side effects in mice through single-cell RNA sequencing and genetic knockout experiments.

This study shows that gut microbiota differences between mouse strains contribute to varied metabolic responses to high fructose consumption, with Akkermansia playing a key protective role.

This study investigates prenatal Bisphenol A exposure in mice, identifying multi-tissue omics disruptions linked to cardiometabolic disorders.