David Pruyne

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

This study shows Fhod3 is essential for maintaining myofibril stability during skeletal muscle growth in zebrafish but not for initial myofibril assembly.

The sole essential low molecular weight tropomyosin isoform of Caenorhabditis elegans is essential for pharyngeal muscle function.

This study identifies LEV-11E as the sole essential low molecular weight tropomyosin isoform in C. elegans, critical for pharyngeal muscle function despite not stabilizing thin filaments.

FHOD-1/profilin-mediated actin assembly protects sarcomeres against contraction-induced deformation in C. elegans

This study shows FHOD-1 and profilin cooperate to stabilize sarcomere Z-lines in C. elegans by promoting actin assembly and preventing muscle deformation during contraction.

FHOD-1 is the only formin in Caenorhabditis elegans that promotes striated muscle growth and Z-line organization in a cell autonomous manner

This study identifies FHOD-1 as the sole formin required for striated muscle growth and Z-line organization in C. elegans through cell autonomous mechanisms.