Matthias Gaestel

Septin7 is essential in early hematopoiesis, but redundant at later stages

This study shows Septin7 is essential for early hematopoiesis but dispensable at later stages, as its deletion in hematopoietic cells leads to engraftment failure but not steady-state blood lineage defects.

MK2/p38/p53 suppress basal IL-1β and non-canonical NF-κB signaling

The paper shows that MK2/p38/p53 suppress basal IL-1β and non-canonical NF-κB signaling by regulating p53 and RelB cleavage.

A Cdc42-Borg4-Septin 7 axis regulates HSCs polarity and function

This study identifies a Cdc42-Borg4-Sep7 axis that regulates HSC polarity and function by controlling the polar distribution of these proteins and affecting engraftment potential and LMPP frequency.

Alternative translation initiation generates a functionally distinct isoform of the stress-activated kinase MK2

The paper identifies an alternative translation initiation site in MK2 mRNA that generates a long isoform with distinct functional properties compared to the short isoform.