Julien Pichon

Karyotypic evolution in a diverse primate clade and the role of chromosomal fissions as barriers to gene flow

This study investigates chromosomal fissions in guenons, finding they may act as barriers to gene flow but with inconsistent evidence across species.

Functional divergence of regulatory and conventional bovine neutrophils following Mycobacterium bovis infection

This study compares the functional responses of regulatory and conventional bovine neutrophils to Mycobacterium bovis infection, revealing distinct transcriptional, metabolic, and phagocytic profiles.

Characterization of the African Swine Fever Virus transcriptome and the associated innate immune response reveals key features of virulence

This study compares virulent and attenuated ASFV strains to identify differences in viral gene expression and host immune response that contribute to virulence.

Mechanistic insights into the activity of Benzoxaboroles against Cryptosporidium parvum: CPSF3 targeting and resistance implications

This study investigates how benzoxaboroles inhibit CPSF3 in Cryptosporidium parvum, identifies resistance mechanisms, and shows that AN7973 can overcome resistance.

NOD2 stimulation reduces Cryptosporidium parvum level of infection in neonates by promoting intestinal epithelial production of antimicrobial peptides and cell renewing

This study shows that NOD2 stimulation with MDP reduces Cryptosporidium parvum infection in neonatal mice by increasing antimicrobial peptides and epithelial cell renewal.

From tissue to subcellular level : imaging human precision-cut lung slices (PCLS) to gain insight into pandemic bacterial or viral infections

This paper describes a method to generate and image human precision-cut lung slices (PCLS) to study viral and bacterial infections, showing their utility for ex vivo pathogen research.