Author

Ane Metola

Stockholm UniversityORCID 0000-0002-2885-7634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:E. coli· 2 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Gunnar von HEIJNEiD· 5 shared Justin M. WesterfieldiD· 2 shared Ajda Krč· 1 shared Alexandros KatranidisiD· 1 shared Álvaro VillarroeliD· 1 shared Amanda Liljenström· 1 shared Ànna PavlovaiD· 1 shared Arantza Muguruza‐MonteroiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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5 shared papersMolecular Biology

Gunnar von HEIJNEORCID

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5 papers

Recent·Most cited

Quasi-continuous cotranslational compaction and folding of a multidomain protein

Spyridoula Mitsikosta, Justin M. Westerfield, Fátima Pardo‐Ávila, Michael Levitt, Gunnar von HEIJNE, Ane Metola

This study uses Force Profile Analysis to examine the cotranslational folding of Firefly luciferase, revealing a complex, quasi-continuous folding process with multiple intermediate steps.

Nature Communications · Oct 5, 2026Peer-reviewedMolecular Biology

SARS-CoV-2 membrane protein biogenesis

Juan Ortiz‐Mateu, Guy Pearson, Marina Rius-Salvador, Shiva Sedighian, Ànna Pavlova, Josep Alonso-Romero, José M. Acosta‐Cáceres, Ane Metola, Maria Jesús García‐Murria, Mark J. Skehel, James C. Gumbart, Jeremy Graham Carlton, Gunnar von HEIJNE, Manuel M. Sánchez del Pino, Luis Martínez‐Gil, Ismael Mingarro

This study investigates the biogenesis of the SARS-CoV-2 M protein, revealing key steps in its insertion, folding, and oligomerization.

bioRxiv · Jan 20, 2026 · PreprintMolecular Biology

Cotranslational membrane insertion of the voltage-sensitive K+ channel KvAP

Justin M. Westerfield, Petra Kozojedová, Cara Juli, Ane Metola, Gunnar von HEIJNE

The paper investigates the cotranslational membrane insertion of the KvAP voltage-sensitive ion channel using Force Profile Analysis, revealing three distinct insertion steps and the role of charged residues and helical structures.

Proceedings of the National Academy of Sciences · Mar 31, 2025Peer-reviewedMolecular Biology

Calmodulin acts as a chaperone during co-translational folding of the Kv7.2 channel Calcium Responsive Domain.

Arantza Muguruza‐Montero, Jack R. Tait, Sara M‐Alicante, Ane Metola, Eider Núñez, Janire Urrutia, Vanda Šunderlíková, Alexandros Katranidis, Gunnar von HEIJNE, Sander J. Tans, Álvaro Villarroel

This study shows calmodulin acts as a chaperone during co-translational folding of the Kv7.2 channel's calcium responsive domain by stabilizing metastable hairpins.

bioRxiv · Nov 15, 2024 · PreprintMolecular Biology

Residue-by-residue analysis of cotranslational membrane protein integration in vivo

Felix Nicolaus, Ane Metola, Daphne Mermans, Amanda Liljenström, Ajda Krč, Salmo Mohammed Abdullahi, Matthew Zimmer, Thomas F. Miller, Gunnar von HEIJNE

The paper analyzes the residue-specific forces during cotranslational membrane protein integration in E. coli using force profile analysis.

eLife · Feb 8, 2021Peer-reviewedMolecular Biology