Sander J. Tans

This study shows that low CAR affinity improves T-cell synapse dynamics and activation by promoting receptor turnover and signaling.

NuclearIDTracker uses nuclear phenotypic signatures to classify intestinal cell types and track lineage dynamics without fluorescent reporters.

This study directly observes ATP-driven ubiquitin chain handling by Cdc48, revealing non-processive and processive modes of action and their role in ubiquitin unfolding and chain selection.

The paper investigates how two small molecule activators of PP2A, ATUX-8385 and DBK-776, affect the structural stability of the PR65 scaffold using biophysical and computational methods.

This paper introduces BAFS, a method to measure receptor-antigen binding strength in immune synapses with high precision and reduced non-specific binding.

This paper introduces an algorithm that assigns error probabilities to cell tracks, enabling automated analysis and reducing manual curation needs in cell tracking.

The paper shows that BEST4/CA7+ cells and goblet cells depend on each other for survival and differentiation in the intestinal mucus layer.

The paper reveals a temporal control mechanism driven by coupled ribosomes that enables the formation of intertwined protein dimers by bypassing closed monomeric states.

The paper shows co-translational ribosome pairing enables the formation of coiled-coil homodimers from misfolding-prone subunits through chaperone-like interactions between nascent chains.

The paper identifies NAC's role in promoting co-translational folding by interacting with nascent chains at the ribosomal tunnel exit, expanding its known functions in protein biogenesis.

The paper identifies sequential transcriptomic states of tuft cells along the intestinal crypt-villus axis and shows cytokine-specific differentiation into distinct tuft cell phenotypes.

This study shows calmodulin acts as a chaperone during co-translational folding of the Kv7.2 channel's calcium responsive domain by stabilizing metastable hairpins.

The paper shows global regulators enable adaptation to a growth-motility trade-off in E. coli by modulating both phenotypes, while local regulators mainly affect motility.

The paper shows E. coli cells use the cAMP-CRP system to continuously adjust catabolic enzyme expression in response to metabolic fluctuations, revealing noise propagation modes and their regulation.

OrganoidTracker automates cell tracking in organoids using machine learning and manual error correction, achieving high accuracy with minimal manual intervention.

The paper shows that adding XEN cells to mouse gastruloids induces neuroepithelial tissue formation through reciprocal differentiation and WNT signaling inhibition.