Michael Levitt

Quasi-continuous cotranslational compaction and folding of a multidomain protein

This study uses Force Profile Analysis to examine the cotranslational folding of Firefly luciferase, revealing a complex, quasi-continuous folding process with multiple intermediate steps.

Structure-aware Graph Learning Predicts RNA Editability Across Tissues and Species

AdarEdit predicts RNA editability using a structure-aware graph model trained on Alu duplexes across tissues and species, showing strong performance and evolutionary conservation.

PDBCleanV2: A Python Library for Generating Consistent Structure Datasets

PDBCleanV2 generates consistent structure datasets by standardizing labeling, chain names, and numbering for protein structures.

Single-residue effects on the behavior of a nascent polypeptide chain inside the ribosome exit tunnel

The paper uses FPA and MD simulations to study how individual residues in an AP-stalled NC interact with the ribosome exit tunnel, showing residue-specific effects on translational arrest.

Probing interplays between human XBP1u translational arrest peptide and 80S ribosome

This study uses molecular dynamics simulations to investigate XBP1u AP-ribosome interactions and their variants, revealing insights into the mechanism of translational arrest.

Insights on cross-species transmission of SARS-CoV-2 from structural modeling

This study uses structural modeling to analyze ACE2 orthologs and their interactions with SARS-CoV-2 spike protein, identifying mutations that affect susceptibility and suggesting therapeutic applications.