Ànna Pavlova

Modified crRNA variants for precise targeting of point mutations in human mitochondrial DNA by CRISPR-Cas12a

This study identifies modified crRNA variants for precise targeting of point mutations in human mitochondrial DNA using CRISPR-Cas12a, showing effective discrimination and base editing in vitro and in human cells.

SILCS-Guided Feature Encoding Expands Ligand Recognition at an HBV Core Protein Interface

The paper identifies ligands that bind beyond a known hydrophobic pocket at the HBV core protein interface using molecular dynamics and fragment mapping.

SARS-CoV-2 membrane protein biogenesis

This study investigates the biogenesis of the SARS-CoV-2 M protein, revealing key steps in its insertion, folding, and oligomerization.

Antigen receptor competition in CAR-TCR cells changes cytotoxicity outcomes upon spatial antigen separation

The paper investigates how spatial separation of antigens affects cytotoxicity in CAR-TCR cells by analyzing clonotype dynamics and functional TCR contributions.

Machine learning of molecular dynamics simulations provides insights into modulation of viral capsid assembly

This paper uses machine learning to classify molecular dynamics simulations of viral capsid assembly intermediates, distinguishing between apo and CAM-bound states with high accuracy.

The influence of downstream structured elements within mRNA on the dynamics of intersubunit rotation in ribosomes

This study investigates how mRNA structures affect ribosome intersubunit rotation using smFRET and MD simulations.